RT Journal Article
SR Electronic
T1 Incidence and Risk Factors of Contrast-Induced Sialadenitis after Therapeutic Neuroendovascular Procedures
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 523
OP 528
DO 10.3174/ajnr.A8492
VO 46
IS 3
A1 Lee, Sang Hyo
A1 Ban, Seung Pil
A1 Kwon, O-Ki
A1 Kim, Young Deok
A1 Lee, Yongjae
A1 Oh, Chang Wan
A1 Bang, Jae Seung
A1 Lee, Si Un
A1 Kwon, Min-Yong
YR 2025
UL http://www.ajnr.org/content/46/3/523.abstract
AB BACKGROUND AND PURPOSE: Swelling of the salivary glands, known as contrast-induced sialadenitis (CIS), is an adverse reaction to iodide contrast agents. However, the incidence and risk factors of CIS after therapeutic neuroendovascular procedures have not yet been established.MATERIALS AND METHODS: Demographic and procedural factors that may influence the development of CIS were retrospectively analyzed to identify the incidence and risk factors of this condition. A total of 780 patients who underwent therapeutic neuroendovascular procedures between January 1, 2022 and December 31, 2022 were investigated. The risk factors affecting CIS were analyzed by using multivariate logistic regression, and the quantitative degree of association between the volume of contrast administered and occurrence of CIS was determined by using the receiver operating characteristic (ROC) curve.RESULTS: The incidence of CIS after therapeutic neuroendovascular procedures was 4.2%. Multivariate logistic regression analysis showed that female sex (OR = 4.420, 95% CI: 1.377–14.190, P = .013), volume of contrast administered (OR = 1.007, 95% CI: 1.003–1.101, P < .001), and guiding catheter tip located within the external carotid artery (ECA) (OR = 8.701, 95% CI: 3.459–21.885, P < .001) were independently associated with CIS occurrence after therapeutic neuroendovascular procedures. The volume of contrast administered had an area under the ROC curve of 0.723 (95% CI: 0.635–0.810; P < .001), and the optimal cutoff value of the volume of contrast administered was 205 mL (sensitivity: 0.49, specificity: 0.87).CONCLUSIONS: We observed CIS in 4.2% of our patients undergoing therapeutic neuroendovascular procedures. This represents a higher incidence than previously reported. Female sex, volume of contrast administered, and guiding catheter tip located within the ECA are associated with CIS incidence.AUROCarea under the receiver operating characteristic curveBMIbody mass indexCIScontrast-induced sialadenitisECAexternal carotid arteryGFRglomerular filtration rateNSAIDsnonsteroidal anti-inflammatory drugsROCreceiver operating characteristicUSultrasound