PT  - JOURNAL ARTICLE
AU  - Caillé, J M
AU  - Lemanceau, B
AU  - Bonnemain, B
TI  - Gadolinium as a contrast agent for NMR.
DP  - 1983 Sep 01
TA  - American Journal of Neuroradiology
PG  - 1041--1042
VI  - 4
IP  - 5
4099  - http://www.ajnr.org/content/4/5/1041.short
4100  - http://www.ajnr.org/content/4/5/1041.full
SO  - Am. J. Neuroradiol.1983 Sep 01; 4
AB  - Gadolinium chloride (GdCl3) was studied as a contrast agent for nuclear magnetic resonance. This rare-earth element dramatically alters proton resonance (paramagnetic moment = 10.8 Bohr magnetons). Acute toxicity was determined by intravenous injections in mice; mean lethal dose was 100-200 mg of GdCl3 . 6 H2O/kg. Changes in T1 of plasma, kidney, liver, and brain of mice and rats were measured after intravenous injections of GdCl3 solution at a concentration of 60 mg gadolinium metal/kg. The apparatus used was a Wh 270 Brucker with a field of 63 kG. The T1 was found to be significantly decreased in plasma, kidney, and liver.