PT  - JOURNAL ARTICLE
AU  - Bergstrand, G
AU  - Larsson, S
AU  - Bergström, M
AU  - Eriksson, L
AU  - Edner, G
TI  - Cerebrospinal fluid circulation: evaluation by single-photon and positron emission tomography.
DP  - 1983 May 01
TA  - American Journal of Neuroradiology
PG  - 557--559
VI  - 4
IP  - 3
4099  - http://www.ajnr.org/content/4/3/557.short
4100  - http://www.ajnr.org/content/4/3/557.full
SO  - Am. J. Neuroradiol.1983 May 01; 4
AB  - Gamma camera cisternography after intrathecal administration of 111In-DTPA is a widely used and well established technique for studies of cerebrospinal fluid (CSF) circulation. The radiation dose from 111In, however, is a limiting factor that sometimes seriously affects the image quality and, hence, correct interpretation. This investigation was designed to assess the value of tomographic techniques for studies of CSF flow. Single-photon emission computed tomography (SPECT) was performed on 15 patients by means of the Karolinska Hospital rotating gamma camera system after injection of 111In-DTPA or 99mTc-DTPA. The combination of SPECT and 99mTc-DTPA proved to be a valuable technique. It permits a clear evaluation of the location of the isotope intracranially and its precise relation to the ventricles. Positron emission tomography (PET) applied after intrathecal administration of 68Ga-EDTA demonstrates that small amounts of radioactivity can be registered and that PET is a promising technique for the evaluation of CSF dynamics.