PT  - JOURNAL ARTICLE
AU  - Floras, P
AU  - Bidabé, A M
AU  - Caillé, J M
AU  - Simonnet, G
AU  - Lecomte, J M
AU  - Sabathié, M
TI  - Double-blind study of effects of enkephalinase inhibitor on adverse reactions to myelography.
DP  - 1983 May 01
TA  - American Journal of Neuroradiology
PG  - 653--655
VI  - 4
IP  - 3
4099  - http://www.ajnr.org/content/4/3/653.short
4100  - http://www.ajnr.org/content/4/3/653.full
SO  - Am. J. Neuroradiol.1983 May 01; 4
AB  - The side effects in myelography are well known and frequently observed. The most common are headache, nausea, and vomiting. In this study, a rather new compound, Thiorphan, was examined, which displays an antinociceptive activity by inhibiting enkephalinase activity. Forty-two patients received intravenous infusions of Thiorphan before myelography. Another 42 patients were in a control group, and Thiorphan was not administered. In the treated group, postmyelographic headache was found in 24% (versus 52% in the control group). Nausea and vomiting were never seen. Low back pain or sciatica was diminished in 33% of cases. Enkephalin levels in cerebrospinal fluid were measured by a radioreceptor-assay method in both groups without any correlation.