PT  - JOURNAL ARTICLE
AU  - Wang, A M
AU  - Skias, D D
AU  - Rumbaugh, C L
AU  - Schoene, W C
AU  - Zamani, A
TI  - Central nervous system changes after radiation therapy and/or chemotherapy: correlation of CT and autopsy findings.
DP  - 1983 May 01
TA  - American Journal of Neuroradiology
PG  - 466--471
VI  - 4
IP  - 3
4099  - http://www.ajnr.org/content/4/3/466.short
4100  - http://www.ajnr.org/content/4/3/466.full
SO  - Am. J. Neuroradiol.1983 May 01; 4
AB  - This is a restrospective correlative study of cranial computed tomography (CT) and autopsy findings in 50 patients after central nervous system radiation therapy and/or chemotherapy. Most patients had more than one posttherapy CT scan and all cases were autopsied. Twenty-six cases (52%) showed no posttherapy CT changes. In 18 cases (36%) enlargement of intracranial subarachnoid spaces and/or ventricles was seen on CT, but only two of these cases showed gross atrophy on postmortem examination; even in these, the cortex was histologically normal, suggesting that these CT changes may be reversible. In six cases a decrease in white-matter density was seen on CT. Two of these cases were histologically normal, two cases showed some white-matter rarefaction, one case contained multiple foci of white-matter and vessel well necrosis, and one case had progressive multifocal leukoencephalopathy.