PT  - JOURNAL ARTICLE
AU  - Ebner, F
AU  - Ranner, G
AU  - Slavc, I
AU  - Urban, C
AU  - Kleinert, R
AU  - Radner, H
AU  - Einspieler, R
AU  - Justich, E
TI  - MR findings in methotrexate-induced CNS abnormalities.
DP  - 1989 Sep 01
TA  - American Journal of Neuroradiology
PG  - 959--964
VI  - 10
IP  - 5
4099  - http://www.ajnr.org/content/10/5/959.short
4100  - http://www.ajnr.org/content/10/5/959.full
SO  - Am. J. Neuroradiol.1989 Sep 01; 10
AB  - MR of the brain was performed in eight patients (mean age, 14.9 years) with osteogenic sarcoma during or after IV treatment with high-dose methotrexate. MR detected brain abnormalities in four patients, three of whom had concomitant neurologic dysfunction. Pathologic findings demonstrated on MR were (1) chronic brain edema, demonstrable over a period of 3-14 months (proved by autopsy in one patient); (2) multifocal white matter necrosis; and (3) deep brain atrophy. MR appears to be valuable in the detection of abnormalities induced by treatment with high-dose methotrexate.