RT Journal Article SR Electronic T1 Optimization of sequence parameters in fast MR imaging of the brain with FLASH. JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 357 OP 362 VO 10 IS 2 A1 Stadnik, T W A1 Luypaert, R R A1 Neirynck, E C A1 Osteaux, M YR 1989 UL http://www.ajnr.org/content/10/2/357.abstract AB Owing to the intrinsically complex behavior of the signal intensity of fast gradient-refocusing MR sequences, agreement as to the clinically most useful sequence parameters has not yet been reached. This study evaluates the FLASH (fast low-angle shot) sequence for gray-white matter differentiation on normal volunteers at 1.5 T. The FLASH gradient-echo sequence is essentially T1-dependent. For very fast imaging and T1 weighting, the following parameters yield the best results: a flip angle of 30-50 degrees with TR = 20 and TE = 10. To replace T1-weighted SE by the faster FLASH sequence, the best results are achieved by a flip angle of 70-120 degrees with TR = 150-300 and TE = 10 (or shorter, if possible). The most valuable proton-density aspect is achieved by a flip angle of 30 degrees with TR = 300 and TE = 16.