PT - JOURNAL ARTICLE AU - Hayman, L A AU - Taber, K H AU - Jhingran, S G AU - Killian, J M AU - Carroll, R G TI - Cerebral infarction: diagnosis and assessment of prognosis by using 123IMP-SPECT and CT. DP - 1989 May 01 TA - American Journal of Neuroradiology PG - 557--562 VI - 10 IP - 3 4099 - http://www.ajnr.org/content/10/3/557.short 4100 - http://www.ajnr.org/content/10/3/557.full SO - Am. J. Neuroradiol.1989 May 01; 10 AB - A multicenter prospective study was performed in 49 patients with 77 regions of cerebral infarction. Each patient was evaluated in the acute (0-5 days) and subacute (6-17 days) phases by (1) clinical neurologic examination, (2) CT scans, and (3) N-isopropyl-p-123I-iodoamphetamine (123IMP) single-photon emission CT (SPECT) scans. The abilities of the scans to (1) detect a lesion and (2) predict the clinical outcome were assessed. For lesion detection, 123IMP-SPECT was superior to CT in the first 2 days, but the scans were equally effective 3-5 days after onset. In the subacute phase, IV contrast-enhanced CT was superior to 123IMP-SPECT and unenhanced CT. The clinical outcome was only mildly correlated with the results of the acute and subacute 123IMP-SPECT and the acute CT scans. Reduction in lesion size on the subacute scans did not correlate with clinical improvement. We conclude that the parameters measured by CT and 123IMP-SPECT in patients with acute cerebral infarction cannot reliably be used to predict clinical outcome. 124I contamination of 123IMP and the use of low-energy collimators may have decreased lesion detectability.