PT  - JOURNAL ARTICLE
AU  - Hou, G.Q.
AU  - Sun, J.C.
AU  - Zhang, X.J.
AU  - Shen, B.X.
AU  - Zhu, X.J.
AU  - Liang, L.
AU  - Zhang, X.L.
TI  - MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings
AID  - 10.3174/ajnr.A2987
DP  - 2012 Mar 22
TA  - American Journal of Neuroradiology
4099  - http://www.ajnr.org/content/early/2012/03/22/ajnr.A2987.short
4100  - http://www.ajnr.org/content/early/2012/03/22/ajnr.A2987.full
AB  - SUMMARY: Our aim was to better understand and improve the accuracy of the preoperative diagnosis of intraspinal MM by a combined analysis of MR imaging and pathologic findings. All 5 patients had undergone unenhanced and contrast-enhanced MR imaging examinations. All tumor samples had immunohistochemical reactions to HMB-45, vimentin, S-100, EMA, and Leu-7 antibodies. All 5 cases were located in the intradural extramedullary compartment. Two cases had multifocal lesions, and 3 cases were solitary. Two cases showed homogeneously strong enhancement, and 3 cases showed moderate enhancement on contrast-enhanced T1WI. The tumor cells had positive reactions to HMB-45, vimentin, and S-100 antibodies. MR imaging plays an important role in the detection and diagnosis of intraspinal MM. Final diagnosis should be based on histopathology and IHC examinations. Abbreviations EMAepithelial membrane antigenHMB-45human melanoma black-45IHCimmunohistochemistryMMmeningeal melanocytoma