PT  - JOURNAL ARTICLE
AU  - Watts, R.
AU  - Steinklein, J.M.
AU  - Waldman, L.
AU  - Zhou, X.
AU  - Filippi, C.G.
TI  - Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI
AID  - 10.3174/ajnr.A5931
DP  - 2019 Apr 01
TA  - American Journal of Neuroradiology
PG  - 648--651
VI  - 40
IP  - 4
4099  - http://www.ajnr.org/content/40/4/648.short
4100  - http://www.ajnr.org/content/40/4/648.full
SO  - Am. J. Neuroradiol.2019 Apr 01; 40
AB  - SUMMARY: On the basis of animal models, glymphatic flow disruption is hypothesized to be a factor in the development of Alzheimer's disease. We report the first quantitative study of glymphatic flow in man, combining intrathecal administration of gadobutrol with serial T1 mapping to produce contrast concentration maps up to 3 days postinjection, demonstrating performing a quantitative study using the techniques described feasibility and providing data on pharmacokinetics.ADAlzheimer's disease