PT  - JOURNAL ARTICLE
AU  - do Amaral, L.L.F.
AU  - Ferreira, R.M.
AU  - Ferreira, N.P.F.D.
AU  - Mendonça, R.A.
AU  - Marussi, V.H.R.
AU  - da Cunha, J.L.
AU  - Maçaranduba, B.R.
AU  - Medeiros, J.D.
TI  - Combined Pituitary Hormone Deficiency and PROP-1 Mutation in Two Siblings: A Distinct MR Imaging Pattern of Pituitary Enlargement
AID  - 10.3174/ajnr.A0545
DP  - 2007 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1369--1370
VI  - 28
IP  - 7
4099  - http://www.ajnr.org/content/28/7/1369.short
4100  - http://www.ajnr.org/content/28/7/1369.full
SO  - Am. J. Neuroradiol.2007 Aug 01; 28
AB  - SUMMARY: Mutations of the PROP-1 gene are the most frequent genetic defect in patients with combined pituitary hormone insufficiency. We present the cases of 2 siblings with PROP-1 mutations whom we observed longitudinally. Their initial pituitary MR imaging examinations showed identical findings: an enlarged adenohypophysis, with striking hypointensity on T2-weighted images and slight hyperintensity on T1-weighted images. In one of the children, the follow-up MR imaging obtained 3 years after hormonal replacement revealed a decrease in the size of the anterior pituitary lobe.