PT  - JOURNAL ARTICLE
AU  - Pareto, D.
AU  - Garcia-Vidal, A.
AU  - Alberich, M.
AU  - Auger, C.
AU  - Montalban, X.
AU  - Tintoré, M.
AU  - Sastre-Garriga, J.
AU  - Rovira, À.
TI  - Ratio of T1-Weighted to T2-Weighted Signal Intensity as a Measure of Tissue Integrity: Comparison with Magnetization Transfer Ratio in Patients with Multiple Sclerosis
AID  - 10.3174/ajnr.A6481
DP  - 2020 Mar 01
TA  - American Journal of Neuroradiology
PG  - 461--463
VI  - 41
IP  - 3
4099  - http://www.ajnr.org/content/41/3/461.short
4100  - http://www.ajnr.org/content/41/3/461.full
SO  - Am. J. Neuroradiol.2020 Mar 01; 41
AB  - SUMMARY: The study aim was to compare the ratio of T1WI to T2WI signal intensity (T1/T2) with magnetization transfer ratio, a marker of myelin integrity, in patients with multiple sclerosis. A moderate correlation (r = 0.50, P = .034) was found between the magnetization transfer ratio and T1/T2 in normal-appearing gray matter, and a strong correlation for normal-appearing white matter (r = 0.63, P = .005) and lesions (r = 0.70, P = .001). Results suggest that besides myelin integrity, other factors may be playing a role in T1/T2 measures.EDSSExpanded Disability Status ScaleMTRmagnetization transfer ratioNAGMnormal-appearing gray matterNAWMnormal-appearing white matterCSFcerebrospinal fluid