PT  - JOURNAL ARTICLE
AU  - Wang, J.
AU  - You, H.
AU  - Liu, J.-F.
AU  - Ni, D.-F.
AU  - Zhang, Z.-X.
AU  - Guan, J.
TI  - Association of Olfactory Bulb Volume and Olfactory Sulcus Depth with Olfactory Function in Patients with Parkinson Disease
AID  - 10.3174/ajnr.A2350
DP  - 2011 Apr 01
TA  - American Journal of Neuroradiology
PG  - 677--681
VI  - 32
IP  - 4
4099  - http://www.ajnr.org/content/32/4/677.short
4100  - http://www.ajnr.org/content/32/4/677.full
SO  - Am. J. Neuroradiol.2011 Apr 01; 32
AB  - BACKGROUND AND PURPOSE: Olfactory dysfunction is commonly associated with IPD. We here report the association of OB volume and OS depth with olfactory function in patients with PD. MATERIALS AND METHODS: Morphometric analyses by using MR imaging and the Japanese T&T olfactometer threshold test were used to evaluate olfactory structure and function in 29 patients with PD and 29 age- and sex-matched healthy controls. RESULTS: The olfactory recognition thresholds were significantly higher in patients with PD than in healthy controls (3.82 ± 1.25 versus 0.45 ± 0.65, P < .001). Olfactory atrophy with reductions in the volume of the OB (37.30 ± 10.23 mm3 versus 44.87 ± 11.84 mm3, P < .05) and in the depth of OS (8.90 ± 1.42 mm versus 9.67 ± 1.24 mm, P < .05) was observed in patients with PD but not in controls. Positive correlations between olfactory performance and OB volumes were observed in both patients with PD (r = −0.45, P < .0001) and in controls (r = −0.42, P < .0001). In contrast, there was no significant correlation between the depth of OS and olfactory function in either cohort. CONCLUSIONS: The results provide evidence that early olfactory dysfunction in patients with PD may be a primary consequence of damage to the OB. Neuroimaging of olfactory structures together with the assessment of olfactory function may be used to identify patients with PD. DWIdiffusion-weighted imagingIPDidiopathic Parkinson diseaseOBolfactory bulbOSolfactory sulcusPDParkinson diseaseSEMstandard error of the meanSNpcsubstantia nigra pars compactaT&TToyota and Takagi