Comparison of imaging and clinical characteristics between patient groups by the presence of a tegmental brainstem dysplasia (severe brainstem malformation)
| Variable | Tegmental Brainstem Dysplasia (No.) (%) | OR (95% CI) | P Value | |
|---|---|---|---|---|
| Present (Severe Group) | Absent (Mild Group) | |||
| Mortality | 7 (46.7%) | 8 (15.1%) | 4.922 (1.392–17.399) | .01a |
| Severe macrocrania | 10 (62.5%) | 14 (24.6%) | 5.119 (1.576–16.629) | .004b |
| Prematurity | 6 (42.87%) | 14 (34.4%) | 1.446 (0.419–4.997) | .559a |
| Genetic abnormalities | 5 (31.2%) | 17 (29.8%) | 1.912 (0.319–11.471) | .677b |
| Bulbar dysfunction | 12 (75%) | 20 (36.4%) | 5.250 (1.492–18.470) | .006a |
| Enteral feeding tube dependency | 12 (75%) | 28 (50.9%) | 2.893 (0.830–10.087) | .087a |
| Seizure | 11 (68.%) | 20 (35.7%) | 3.960 (1.205–13.018) | .019a |
| Extreme vermian hypoplasia | 9 (56.25%) | 3 (5.3%) | 23.143 (5.034–106.401) | <.001b |
| Cerebellar dysplasia | 11 (68.8%) | 16 (28.1%) | 5.638 (1.690–18.805) | .003a |
| Hydrocephalus | 13 (81.3%) | 30 (52.6%) | 3.900 (1.002–15.177) | .04a |
| Corpus callosum agenesis | 12 (75.0%) | 25 (43.9%) | 3.840 (1.104–13.358) | .028a |
| Interhemispheric cyst | 9 (56.3%) | 2 (3.5%) | 35.357 (6.317–197.9) | <.001b |
| Gray matter migration | 10 (62.5%) | 8 (14%) | 10.208 (2.901–35.923) | <.001b |
| Calcification or hemorrhage | 4 (25%) | 8 (14%) | 2.042 (0.526–7.924) | .444b |
| Posterior fossa perimeter (mean) (mm) | 252. 4 (SD, 110.3) | 149.9 4 (SD, 100.6) | – | .002c |