Pooled subgroup analysis and metaregression for CTP for detection of delayed cerebral ischemia
| Studies | Pooled Sensitivity (%) | Pooled Specificity (%) | Positive LR | Negative LR | Diagnostic OR | |
|---|---|---|---|---|---|---|
| (95% CI) | (95% CI) | |||||
| CTP <72 hr | 5 | 55.8 (27.3–80.8) | 93.7 (66.8–99.1) | 8.81 (1.12–68.38) | 0.47 (0.23–0.96) | 18.0.66 (1.45–239.63) |
| CTP >72 hr | 5 | 84.5 (57.3–95.7) | 84.9 (48.0–97.2) | 5.60 (1.14–27.60) | 0.18 (0.05–0.65) | 30.73 (2.50–378.08) |
| Relative sensitivity >72 hr vs <72 hr = 1.52 (95% CI, 0.85–2.68); P = .11; relative specificity >72 hr vs <72 hr = 0.91 (95% CI, 0.67–1.22); P = .47 | ||||||
| MTT threshold | 5 | 75.4 (61.6–85.4) | 66.6 (51.3–79.0) | 2.25 (1.33–3.81) | 0.37 (0.20–0.69) | 6.10 (1.98–18.78) |
| MTT qualitative | 5 | 67.9 (56.9–85.9) | 78.8 (69.2–85.9) | 3.19 (2.09–4.89) | 0.41 (0.29–0.57) | 7.86 (3.92–15.76) |
| Relative sensitivity threshold vs qualitative = 1.14 (95% CI, 0.92–1.40); P = .24; relative specificity threshold vs qualitative = 0.82 (95% CI, 0.66–1.02); P = .10 | ||||||
| CBF | 7 | 74.1 (60.8–84.1) | 87.4 (75.1–94.2) | 5.91 (2.99–11.67) | 0.30 (0.20–0.45) | 19.96 (8.99–44.32) |
| CBV | 7 | 64.3 (50.6–75.9) | 73.9 (60.1–84.1) | 2.45 (1.72–3.52) | 0.48 (0.37–0.64) | 5.08 (3.16–8.17) |
| Relative sensitivity CBV vs CBF = 0.88 (95% CI, 0.69–1.12); P = .30; relative specificity CBV vs CBF = 0.86 (95% CI, 0.70–1.05); P = .13 | ||||||
| CBF | 8 | 78.9 (72.7–84.0) | 79.6 (64.7–89.3) | 3.87 (2.11–7.10) | 0.27 (0.19–0.36) | 14.62 (6.38–33.49) |
| MTT | 8 | 81.5 (73.5–87.5) | 79.2 (69.9–86.2) | 3.91 (2.68–5.71) | 0.23 (0.16–0.34) | 16.77 (9.31–30.22) |
| Relative sensitivity MTT vs CBF =1.03 (95% CI, 0.93–1.14); P = .64; relative specificity MTT vs CBF = 1.02 (0.85–1.23); P = .85 | ||||||
| CBV | 6 | 70.6 (63.0–77.2) | 68.5 (59.9–75.9) | 2.24 (1.72–2.91) | 0.43 (0.33–0.56) | 5.21 (3.24–8.40) |
| MTT | 6 | 84.3 (76.9–89.7) | 74.4 (66.7–80.9) | 3.30 (2.43–4.47) | 0.21 (0.14–0.33) | 15.64 (8.03–30.46) |
| Relative sensitivity MTT vs CBV = 1.182 (95% CI, 1.05–1.33); P = .009; relative specificity MTT vs CBV = 1.09 (95% CI, 0.94–1.25); P = .27 | ||||||