Comparison of Known-Group Validity (Discrimination of 28 Patients with AD from 28 Control Subjects) with Linear and Volumetric MR-Based Measures of MTL Atrophy in the MR Group
| Control Group | AD Group | Sensitivity (95% CI)* | ||
|---|---|---|---|---|
| Mean Crude Measure ± SD (mm) | Mean Crude Measure ± SD (mm) | Mean W-score ± SD | ||
| Radial width of the temporal horn (mm) | ||||
| Right | 3.7 ± 1.1 | 6.7 ± 2.0 | 3.0 ± 1.9 | 76% (56%–89%) |
| Left | 3.3 ± 1.5 | 5.8 ± 2.5 | 1.7 ± 1.6 | 51% (32%–70%) |
| Largest | 4.1 ± 1.2 | 7.2 ± 2.1 | 2.7 ± 1.7 | 73% (53%–87%) |
| Coronal width of the temporal horn (mm) | ||||
| Right | 3.0 ± 1.2 | 5.3 ± 2.3 | 2.4 ± 2.3 | 63% (43%–80%) |
| Left | 3.2 ± 1.1 | 6.1 ± 2.3 | 3.4 ± 2.7 | 74% (54%–88%) |
| Largest | 3.4 ± 1.2 | 6.5 ± 2.3 | 2.7 ± 2.1 | 69% (49%–84%) |
| Hippocampal volume (mm3) | ||||
| Right | 1951 ± 335 | 1309 ± 361 | 1.7 ± 1.2 | 52% (33%–71%) |
| Left | 1797 ± 288 | 1263 ± 344 | 1.7 ± 1.0 | 52% (33%–71%) |
| Smallest | 1774 ± 282 | 1191 ± 336 | 2.3 ± 1.2 | 71% (51%–86%) |
Note.—P < .0005 for difference between groups on t test for all measures. W scores are age-standardized values, that is, the number of SD away from the age-specific atrophy value of control subjects (control W scores, 0 ± 1.0). Greater absolute values indicate greater atrophy.
* Values computed by modeling W scores of Patients with AD and control subjects with specificity set at 95%.