Main MR imaging signal changes and correspondent metabolic profile of MR spectroscopy during the evolution of the disease
| Months after Onset | MR Imaging | Cho/Cr | NAA/Cr | Lactate | Lipids |
|---|---|---|---|---|---|
| 1 | T2 hyperintensity of the entire corpus callosum; foci of in the centrum semiovale | 1.35 | 1.98 | ++ | – |
| 2 | Unchanged | 1.17 | 1.67 | + | – |
| 4 | Persistent hyperintensity in the splenium and posterior half of the body of the corpus callosum; corpus callosum slightly atrophic | 1.06 | 1.26 | – | + |
| 11 | Slight hyperintensity of the splenium; moderate atrophy of the corpus callosum | 0.87 | 1.45 | – | – |
| Normal range | 0.9–1.3 | 1.8–2.4 | – | – |
Note.—Cho indicates choline; Cr, creatine; NAA, N-acetylaspartate.