rCBV, Cho/Cr ratio, and Cho/NAA ratio together for differentiation between low- and high-grade glioma
| Description | Sensitivity | Specificity | PPV | NPV | C2 Error | C1 Error |
|---|---|---|---|---|---|---|
| Minimum C2 Error* | 93.3 | 60.0 | 87.5 | 75.0 | 15.0 | 23.3 |
| Minimum C1 Error† | 70.8 | 92.5 | 96.6 | 51.4 | 23.7 | 18.3 |
| Same sensitivity as cMRI | 72.5 | 87.5 | 94.6 | 51.5 | 23.8 | 20.0 |
| Same specificity as cMRI | 89.2 | 65.0 | 88.4 | 66.7 | 16.9 | 22.9 |
Note.—Conventional MR imaging (cMRI) sensitivity 72.5%, specificity 65.0%, PPV 86.1%, NPV 44.1%, C2 error 29.4%, and C1 error 31.8%.
* C2 = the percentage of observed data points misclassified.
† C1 = 1 − (sensitivity + specificity)/2. This maximizes the average of sensitivity and specificity.