Clinical, pathological, and imaging findings of four patients with the diagnosis of atypical teratoid/rhabdoid tumor
| Patient No. | Age/Sex | Symptoms/Findings | CT and MR Imaging Findings | Resection | Pathologic Findings | Outcome | |||
|---|---|---|---|---|---|---|---|---|---|
| Location/Invasion | Composition | Enhancement | Calcification | ||||||
| 1 | 9 mo/F | R-sided weakness | Cystic L frontoparietal occipital, skull destruction | Solid and cystic, peripheral cyst | Thick irregular nodular rim enhancement | Yes | GTR | + Vimentin | 7 mo no therapy other than surgery |
| + GFAP | |||||||||
| + EMA | |||||||||
| + Cytokeratins | |||||||||
| − Synaptophysin | |||||||||
| − Actin | |||||||||
| 2 | 8 mo/F | Poor feeding, macrocephaly, lethargy | L hemisphere, infiltrative to adjacent parenchyma | Solid and cystic | Thick irregular nodular rim enhancement | Yes | STR | + Vimentin | 5 mo with therapy |
| + GFAP | |||||||||
| + EMA | |||||||||
| 3 | 16 y/F | R-sided weakness, numbness of the feet | Tectal/pineal, brain stem invasion | Solid and cystic, peripheral cyst | Intense enhancement | Yes | STR | + Vimentin | 3 mo with therapy |
| + GFAP | |||||||||
| + EMA | |||||||||
| − Synaptophysin | |||||||||
| − Actin | |||||||||
| − Ki-1 | |||||||||
| 4 | 11 mo/M | Multiple cranial nerve deficits | Brain stem/R CPA, brain stem invasion | Solid and cystic, peripheral cyst | Moderate enhancement | Yes | STR | + Vimentin | 1 mo with therapy |
| + GFAP | |||||||||
| + EMA | |||||||||
| + Cytokeratins | |||||||||
Note.—F indicates Female; M, male; R, right; L, left; CPA, cerebellopontine angle; GTR, gross total resection; STR, subtotal resection; GFAP, glial fibrillary acidic protein; EMA, epithelial membrane antigen.