Subject characteristics stratified by age
| Demographics | 20–34 Years(n = 44) | 35–73 Years (n = 43) | P |
|---|---|---|---|
| Age (years) | 25.0 ± 4.5 | 51.0 ± 8.8 | <.001 |
| Male gender (%) | 59.0 | 53.5 | NS |
| Education (years) | 14.3 ± 3.5 | 12.9 ± 3.7 | .133 |
| Positive SPHERE (%) | 25.0 | 9.3 | NS |
| Alcohol consumers (%) | 40.0 | 39.5 | NS |
| Left handers (%) | 15.9 | 11.6 | NS |
| Volumetric MRI | |||
| Global GM | 783 ± 88 | 713 ± 73 | <.001 |
| Global WM | 467 ± 64 | 465 ± 51 | .967 |
| Global CSF | 308 ± 43 | 326 ± 51 | .051 |
| Psychometrics | |||
| Attention switching (errors) | 0.61 ± 0.95 | 1.4 ± 1.8 | .004 |
| Executive maze (seconds) | 125 ± 55 | 257 ± 113 | <.001 |
| Digit span (score/14) | 7.3 ± 2.2 | 7.2 ± 1.7 | .082 |
| Reaction time (ms) | 714 ± 206 | 717 ± 104 | .926 |
| Tapping | 160 ± 38 | 156 ± 42 | .693 |
| Estimated IQ | 104 ± 9 | 107 ± 7 | .789 |
Note:—NS indicates nonsignificant; SPHERE, Somatic and Psychological Health Report; GM, gray matter; WM, white matter.