Table 2:

Correlation coefficients between clinical measurements and net lesion volume change and annual lesion volume change per year

Measurement	Net Lesion Volume Change, cm³		Annual Lesion Volume Change, cm³/y
Measurement	SSEG, R, P	CSEG, R, P	SSEG, R, P	CSEG, R, P
Net BPF change	−0.446, 0.046^*	−0.180, 0.421	N/A	N/A
Annual BPF change	N/A	N/A	−0.430, 0.055^†	−0.232, 0.299
Interval time between MR imaging scans	0.234, 0.295	0.151, 0.499	N/A	N/A
Disease duration	N/A	N/A	−0.508, 0.023^*	−0.360, 0.108

Note:—CSEG indicates serial single time-point conventional segmentation; SSEG, segmentation of subtraction images; BPF, brain parenchymal fraction; N/A, nonapplicability of a paired correlation. SSEG reveals relationships with net BPF change and disease duration, whereas CSEG does not.
* Significant results.
† Nearly significant results.