“Apparent” citrate concentrations (mmol/kg) and prevalence in common pediatric brain tumors
| All | DIBSG | A/AA | E/AE | MBL | PA | |
|---|---|---|---|---|---|---|
| Subjects | 85 | 12 | 14 | 14 | 22 | 23 |
| Mean Cit | 2.3 ± 1.7 | 4.0 ± 1.1 | 2.6 ± 1.8 | 2.9 ± 2.2 | 1.9 ± 1.2* | 1.4 ± 1.1** |
| Cit CRLB | 49 ± 41% | 22 ± 7% | 37 ± 25% | 46 ± 67% | 56 ± 37%* | 64 ± 37%** |
| #CRLB < 25% | 26 (31%) | 8 (67%) | 5 (36%) | 5 (36%) | 5 (23%) | 3 (13%) |
Note:—Cit indicates citrate; DIBSG, diffuse intrinsic brain stem glioma; A/AA, low-grade and anaplastic astrocytoma; E/AE, low-grade and anaplastic ependymoma; MBL, medulloblastoma; PA, pilocytic astrocytoma; CRLB, Cramer-Rao lower bounds; #CLRB < 25%, number of subjects in whom CRLB for Cit was less than 25%.
Represents significance compared with DIBSG.
* P < .001.
** P < .0001. Mean CRLB were computed from all spectra.