Sample brain SPECT compounds and applications

Nuclide	Half-Life	Compound	Acronym	Measurement
¹³³Xe	5.24 days	¹³³Xenon	¹³³Xe	rCBF
¹²³I	13.2 hours	¹²³I-isopropyliodoamphetamine	¹²³I-IMP	rCBF
Tc99m	6.02 hours	Tc99m-hexamethylpropyleneamineoxime	Tc99m-HMPAO	rCBF
Tc99m	6.02 hours	Tc99m-ethyl cysteinate dimer (bicisate)	Tc99m-ECD	rCBF
Tc99m	6.02 hours	Tc99m-diethylenetriaminepentaacetic acid	Tc99m-DTPA	CSF, brain death
Tc99m	6.02 hours	Tc99m-pertechnetate	Tc99m-TcO₄	CSF, brain death
¹¹¹In	2.83 days	¹¹¹In-diethylenetriaminepentaacetic acid	¹¹¹In-DTPA	CSF, brain death
⁶⁷Ga	78.3 hours	⁶⁷Ga-ethylenediaminetetraacetic acid	⁶⁷Ga-EDTA	Blood-brain barrier permeability
¹²³I	13.2 hours	¹²³Iomazenil	¹²³I-IMZ	Central type benzodiazepine-receptor binding²⁰
¹²³I	13.2 hours	¹²³I-2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine	¹²³I-ADAM	Serotonin transporter imaging²¹
¹²³I	13.2 hours	¹²³I-ß-carbomethoxy-3-ß-(4-iodophenyl)-tropane	¹²³I-CIT	Dopamine and serotonin transporters²²
¹²³I	13.2 hours	¹²³I-iodobenzofuran	¹²³I-IBF	Dopamine D-2 receptor ligand²³
¹²³I	13.2 hours	¹²³I-iodobenzamide	¹²³I-IBZM	Dopamine D-2 receptor ligand^24,25
Tc99m	6.02 hours	Tc99m-TRODAT	Tc99m-TRODAT	Dopamine transporter sites²⁶
Tc99m	6.02 hours	Tc99m-pyrophosphate	Tc99m-PPi	Bone scanning, TMJ^27,28
Tc99m	6.02 hours	Tc99m-methylene diphosphonate	Tc99m-MDP	Bone scanning, TMJ^28,29
¹¹¹In	2.83 days	[¹¹¹In-DOTA⁰,D-Phe¹,Tyr³] octreotide	¹¹¹In-DOTA-TOC	Somatostatin receptor imaging³⁰
Tc99m	6.02 hours	Tc99m-hydrazinonicotinyl-Tyr³-octreotide	Tc99m-HYNIC-TOC	Somatostatin receptor imaging
¹¹¹In	2.83 days	¹¹¹In-pentetreotide	¹¹¹In-pentetreotide	Somatostatin receptor imaging³¹
¹²³I	13.2 hours	[¹²³I]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine	¹²³I-5IA	Nicotinic acetylcholine receptors³²
¹²³I	13.2 hours	6-iodo-2-(4′-dimethylamino-)phenylimidazo[1,2-a]pyridine	¹²³I-IMPY	β-amyloid plaque imaging³³

Note:—TMJ indicates temporomandibular joint; CBF, relative cerebral blood flow; TRODAT, [2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3,2,1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiolato(3-)-N2,N2′,S2,S2′]oxo-[1R-(exo-exo)].