Estimated means and 95% CIs of BBBP measurements according to the Patlak model and the parameters describing the quality of the linear regression*
| First-Pass | Delayed Phase | P Value | |
|---|---|---|---|
| Ischemic ROIs (N = 290) | |||
| BBBP (95% CI) | 7.63 (4.78–12.19) | 1.31 (1.03–1.68) | <.001 |
| √MSE × 103 (95% CI) | 0.59 (0.36–0.96) | 0.089 (0.073–0.11) | <.001 |
| R (95% CI) | 0.53 (0.46–0.61) | 0.69 (0.59–0.78) | <.001 |
| Nonischemic ROIs (N = 1560) | |||
| BBBP (95% CI) | 2.81 (2.42–3.27) | 1.05 (0.97–1.14) | <.001 |
| √MSE × 103 (95% CI) | 0.18 (0.14–0.24) | 0.041 (0.035–0.048) | <.001 |
| R(95% CI) | 0.57 (0.52–0.61) | 0.85 (0.81–0.88) | <.001 |
Note:—ROI = regions of interest; BBBP, blood-brain barrier permeability; √MSE, squareroot mean squared errors.
* A √MSE close to 0 indicates a smaller spread of data points around the line, corresponding to a better fit. An R close to 1 indicates a stronger linearity.