Location and Talairach coordinates of significant clusters of GM volume loss in patients with h-ET or a-ET compared with controls, when total GM or TIV was included in the ANCOVA*
| Pcorrected | Cluster (κ) | Talairach Coordinates (x/y/z) | Location | |
|---|---|---|---|---|
| GM | ||||
| h-ET group | .000 | 9769 | 8/−48/−7 | R paravermal lob. IV |
| 3/−51/−14 | Vermis lob. IV | |||
| −10/−45/−15 | L paravermal lob. IV | |||
| a-ET group† | .598 | 3770 | 13/−46/−17 | R paravermal lob. IV |
| TIV | ||||
| h-ET group | .000 | 18728 | 15/−48/−10 | R paravermal lob. IV |
| 5/−46/−12 | Vermis lob. IV | |||
| −14/−47/−18 | L paravermal lob. IV | |||
| a-ET group† | .998 | 530 | 11/−51/−4 | R paravermal lob. III |
Note:—R indicates right; L, left; Lob., lobule; GM, gray matter; h-ET, arm and head tremor; a-ET, arm tremor; TIV, total intracranial volume.
* GM volume loss in the h-ET and a-ET groups relative to controls, accounting for differences in total GM and TIV. A threshold of Pcorrected < .001, corrected for multiple comparisons, is used to identify the most significant peaks. Data analyses have been further corrected for age and sex distribution.
† The statistical threshold is released (P < .01, uncorrected for multiple comparisons) to detect subtle morphologic changes in the a-ET group.