Associations between baseline flow characteristics and progression of MR imaging abnormalities
| Lower TCBF | Higher TCBF | Lower CVR | Higher CVR | |
|---|---|---|---|---|
| (< 584 mL/min) | (≥ 584 mL/min) | (< 65%) | (> 65%) | |
| (n = 12) | (n = 13) | (n = 7) | (n = 7) | |
| Mean: 485 | Mean: 683 | Mean: 53% | Mean: 81% | |
| SD: 75 | SD: 86 | SD: 10% | SD: 17% | |
| Δ WMHs in % (SD) | 2.8 (2.7) | 2.0 (1.6) | 2.9 (1.5) | 0.37 (0.03)*** |
| % Subjects with new infarcts | 9/12 (75%) | 9/13 (69%) | 6/7 (86%) | 3/7 (43%) |
| % Subjects with new microbleeds | 4/12 (33%) | 3/13 (23%) | 2/7 (29%) | 1/7 (14%) |
Note:—CVR indicates cerebrovascular reactivity. The Student t test is used for WMHs; the Fisher Exact test, infarcts and microbleeds.
*** Difference (P < .001) between higher and lower.