Comparative overview of measurement parameters of micro-CTA and DSA with intra-arterial contrast application into the ECA
| CTAia | CTAiv | DSA | |
|---|---|---|---|
| Number of mice | 2 | 8 | 5 |
| Scan time | 20 seconds | 40 seconds | ∼2 seconds |
| Radiation dose | 0.25 Gy | 0.5 Gy | ∼0.025 Gy |
| Contrast agent amount | 220 μL | 350 μL | 33 μL |
| Contrast agent concentration | Iomeprol 150 | Iomeprol 300 | Iomeprol 150 |
| Temporal resolution | >20 seconds | >40 seconds | 30 fps |
| Spatial resolution | 16 × 16 × 16 μm | 16 × 16 × 16 μm | 14 × 14 μm |
| CNRmean | 19.0 ± 1.0 | 1.3 ± 0.4 | 10.0 ± 1.8* |
| Smallest detectable vessels | ∼50 μm | ∼80 μm | ∼50 μm |
↵* For measurement of the CNR in DSA, 8 sequentially acquired single projections were averaged. ia indicates intra-arterial; iv, intravenous.