Testing the correspondences between the predicted thalamic nuclei locations and biologically coupled DTI-based thalamocortical connection mapsa
| Cortical Connection Area | Frontal Pole | Superior Frontal Gyrus | Precentral Gyrus | Postcentral Gyrus | Postcentral Gyrus | Cerebellum | Lateral Occipital Cortex | Overall Results |
|---|---|---|---|---|---|---|---|---|
| Associated nucleus | VA | VLa | VLpv | VPLa | VPLp | VLpv | PuL | |
| ACPC registration | 0.46 ± 0.14 | 0.31 ± 0.16 | 0.38 ± 0.2 | 0.14 ± 0.12 | 0.3 ± 0.19 | 0.09 ± 0.09 | 0.08 ± 0.08 | 0.25 ± 0.2 |
| Outline-based SSM | 0.49 ± 0.12 | 0.38 ± 0.15 | 0.41 ± 0.16 | 0.14 ± 0.12 | 0.44 ± 0.15 | 0.14 ± 0.09 | 0.16 ± 0.1 | 0.31 ± 0.19 |
| Hybrid SSM | 0.5 ± 0.12 | 0.41 ± 0.15 | 0.44 ± 0.14 | 0.17 ± 0.11 | 0.48 ± 0.13 | 0.15 ± 0.08 | 0.13 ± 0.1 | 0.33 ± 0.2 |
| Difference between outline-based SSM and ACPC registration | 6.9%b (P = .021) | 22.29%c (P < .001) | 7.7% (P = .212) | 5.3% (P =.666) | 47.7%c (P < .001) | 52.8%c (P < .001) | 97.2%c (P < .001) | 23.3c (P < .001) |
| Difference between hybrid SSM and ACPC registration | 9.1%b (P = .011) | 31.1%c (P < .001) | 15.1%b (P =. 012) | 24.6% (P = 056) | 59.6%c (P < .001) | 58.5c (P < .001001) | 54.0%c (P < .001) | 28.8%c (P < .001) |
| Difference between hybrid SSM and outline-based SSM registration | 2.0% (P = .214) | 7.3%b (P = .023) | 6.8% (P = .056) | 18.3%b (P = 013) | 8.0%b(P =. 019) | 3.7% (P = .562) | −21.9%c (P < .001) | 4.5%c (P < .001) |
Note:—PuL indicates lateral pulvinar.
↵a Correspondence indices (mean ± SD) are given as the ratio of tractography samples reaching 1 particular cortical area from the voxels of a nucleus and from the entire thalamus volume. Comparisons of alignment methods were tested by using a paired Student t test.
↵b Result is significant at the .01 < P < .05 level.
↵c Result is significant at the P < .01 level.