Summary of subject characteristics, broken down by diagnostic categorya
| Variables | All | CN | MCI | AD | P |
|---|---|---|---|---|---|
| No. of subjects | 119 | 72 | 34 | 13 | |
| Age (yr) | 74.5 (7.4) | 74.2 (6.6) | 74.7 (8.6) | 76.4 (8.7) | .61 |
| Education (yr) | 13.2 (4.9) | 12.1 (5.1) | 15.4 (4.2) | 13.5 (4.2) | .0049b |
| Sex (no. of male, % male) | 41; 34.4 | 20; 27.8 | 15; 44.1 | 6; 46.1 | .17 |
| Baseline WMH volume (mL) | 7.7 (9.3) | 6.6 (9.5) | 9.4 (10.0) | 9.0 (8.8) | .088 |
| Follow-up WMH volume (mL) | 9.3 (10.7) | 8.2 (11.0) | 10.5 (9.3) | 12.6 (12.5) | .039c |
| Annual change in WMH (mL/yr) | 0.51 (1.46) | 0.41 (1.40) | 0.47 (1.56) | 1.22 (1.41) | .013b,d |
| Delay (yr) | 3.7 (1.8) | 4.1 (1.7) | 2.9 (2.0) | 3.3 (1.9) | .0063b |
↵a Data presented as mean (SD). χ2 tests were used for categoric variables, and analysis of variance, for continuous variables. For clinical group comparisons, measures of WMH volumes and WMH annual change were log-transformed to normalize variance.
↵b Post hoc comparisons of significant group difference: CN vs MCI.
↵c Post hoc comparisons of significant group difference: CN vs AD.
↵d Post hoc comparisons of significant group difference: MCI vs AD.