Baseline MRI characteristics for all patients, split by progression status at 5 yearsa
| Sustained Disease Progression (n = 90) (mean) (SD) (median) | Stable Disease (n = 90) (mean) (SD) (median) | P Value | |
|---|---|---|---|
| T2-LV | 11.2 (12.9) 6.3 | 4.7 (5.5) 2.8 | <.0001 |
| NWBV | 1488.8 (84.4) 1485.6 | 1524.4 (74.1) 1520.6 | .003 |
| NGMV | 797.9 (53.1) 800.2 | 815.5 (50) 822.7 | .02 |
| NWMV | 690.9 (49.9) 689.5 | 708.9 (37.4) 704.5 | .007 |
| NLVV | 42.6 (15.1) 39.7 | 40 (11.8) 38.9 | .3 |
| NCV | 623.6 (43.3) 627 | 639.7 (41.3) 643.6 | .01 |
| Total NSDGMV | 44.5 (4.5) 44.5 | 46.6 (3.9) 46.4 | .002 |
| NSDGMV structures | |||
| Caudate nucleus | 6.4 (0.8) 6.4 | 6.8 (0.8) 6.8 | .0009 |
| Putamen | 9.4 (1.1) 9.3 | 9.8 (1) 9.9 | .015 |
| Globus pallidus | 3.4 (0.4) 3.4 | 3.5 (0.4) 3.5 | .05 |
| Thalamus | 14.6 (1.8) 14.6 | 15.4 (1.5) 15.2 | .002 |
| Hippocampus | 7.2 (0.8) 7.2 | 7.5 (0.8) 7.6 | .015 |
| Nucleus accumbens | 0.9 (0.2) 0.9 | 1 (0.2) 1 | .018 |
| Amygdala | 2.6 (0.4) 2.6 | 2.6 (0.3) 2.6 | .14 |
Note:—LV indicates lesion volume; NWBV, normalized whole-brain volume; NGMV, normalized gray matter volume; NWMV, normalized white matter volume; NLVV, normalized lateral ventricle volume; NCV, normalized cortical volume; NSDGMV, normalized subcortical deep gray matter volume.
↵a The difference of the means between the groups was calculated using Student t test. The MRI volumes are presented in milliliters.