Factor and receptor families known to play roles in placode induction
| Placode | Inducer Families | |||||
|---|---|---|---|---|---|---|
| FGF | PDGF | RA | Shh | TGFβ family | Wnta | |
| Adenohypophysis | Shh | Nodal, BMP4 | ||||
| Lens | FGFR | BMP4, BMP7 | ||||
| Olfactory | FGF | |||||
| Otic | FGFR | Wnt | ||||
| FGF | ||||||
| Epibranchial | FGFR | |||||
| (VII, IX, X) | FGF | |||||
| Trigeminal | FGF | PDGF | Wnt | |||
| PDGFR | ||||||
Note:—RA indicates retinoic acid; PDGFR, platelet-derived growth factor receptor; FGFR, fibroblast growth factor receptor; PDGF, platelet-derived growth factor.
↵a Modified from Table 2 in McCabe KL, Bronner-Fraser M. Molecular and tissue interactions governing induction of cranial ectodermal placodes. Dev Biol 2009;332:189–95, Elsevier Inc. © All rights reserved.3