Comparing demographics/clinical factors between patients with positive SPAN-100 and patients with negative SPAN-100
| SPAN-100-Negative (n = 218) | SPAN-100-Positive (n = 55) | P Value | |
|---|---|---|---|
| Age (yr) | 68.2 ± 12.5 | 85.5 ± 5.07 | <.001 |
| NIHSS (median, IQR) | 13 (7–18) | 21 (17–24) | <.001 |
| Male sex | 121 (55.5%) | 22 (40) | .04 |
| SBP | 157.7 (139–172) | 156.04 (138–177) | .77 |
| DBP | 84.9 (71–95) | 76.1 (64–87) | .01 |
| Glucose (admission) | 8.1 (5.8–8.1) | 7.6 (6.0–9.0) | .18 |
| Risk factors | |||
| Hypertension | 127 (58.26) | 45 (81.8) | .001 |
| Diabetes mellitus | 43 (19.72) | 10 (18.18) | .79 |
| Hypercholesterolemia | 72 (33.03) | 25 (45.4) | .08 |
| Coronary artery disease | 53 (24.3) | 12 (21.8) | .69 |
| Atrial fibrillation | 64 (29.36) | 19 (34.5) | .45 |
| Smoker | 44 (20.1) | 6 (10.9) | .11 |
| Stroke | 1 (0.46) | 1 (1.82) | .29 |
| Hyperdense sign | 114 (52.53) | 35 (63.64) | .13 |
| ASPECTS (median) (IQR) | 7 (6–9) | 7 (5–8) | .39 |
| Clot burden score | 6 (4–9) | 6 (5–9) | .29 |
| Collateral score | 2 (2–3) | 2 (1–2) | <.001 |
| CBV (median) (IQR) | 14.7 (4.7–34.7) | 34.7 (13.8–60.5) | <.001 |
| CBF | 101.6 (55.3–133.1) | 98.2 (74.6–129.5) | .75 |
| MTT | 104.5 (58.5–133.4) | 98.4 (74.7–130.5) | .69 |
| Time and thrombolysis | |||
| rtPA dose | 63.0 (54–73) | 63.0 (54–72) | .75 |
| Onset to CT | 104.0 (80–148) | 108.0 (75–127) | .62 |
| Onset to rtPA | 161.7 (147) | 143.0 (131) | .03 |
| Outcome | |||
| Recanalization | 119 (55.35) | 33 (61.1) | .44 |
| mRS (at follow-up) | 3 (1–4) | 5 (4–6) | <.001 |
| mRS ≤ 2 | 92 (42.2) | 6 (10.9) | <.001 |
| NIHSS improves >3 in 24 hours | 101 (46.3) | 27 (49) | .71 |
| Hemorrhagic transformation | 78 (38.6) | 28 (56.0) | .02 |
| Hemorrhage infarct | 64 (29.4) | 23 (41.8) | .07 |
| Parenchymal hemorrhage | 26 (11.9) | 9 (16.4) | .37 |
Note:—IQR indicates interquartile range; SBP, systolic blood pressure; DBP, diastolic blood pressure.