Table 3:

Relationship between MRI brain volumetric measures at baseline and evolution of changes over a 48-month period in patients with CIS^{^a}

MRI Brain Volumetric Measures at Baseline	MRI Brain Volume % Changes Over 48 mo
MRI Brain Volumetric Measures at Baseline	WB	WM	GM	Cortical	Lateral Ventricle	SDGM	Thalamus
Normalized WB volume	.712	.004^{^b}	.426	.299	<.001^{^b}	.182	.174
Normalized WM volume	.591	<.001^{^b}	.711	.904	.001^{^b}	.588	.254
Normalized GM volume	.881	.794	.049^{^b}	.075	.004^{^b}	.069	.248
Normalized cortical volume	.847	.774	.075	.040^{^b}	.007^{^b}	.192	.343
Normalized lateral ventricle volume	.066	.156	.935	.587	.013^{^b}	.342	.769
Total normalized SDGM volume	.032^{^b}	.710	.177	.291	.394	.042^{^b}	.457
Normalized thalamic volume	.115	.578	.243	.291	.343	.038^{^b}	<.001^{^b}

Note:—WB indicates whole brain.
↵a All data are reported as P values corrected by the Benjamini-Hochberg procedure. Associations between MRI measures were tested by using mixed-model analysis.
↵b P < .05.