Table 2:

Measurements of CVR, FA, MD, T2, and perfusion metrics in WMH and contralateral homologous NAWM

	WMH (Contralateral to NAWM), Mean (SD)	NAWM (Contralateral to WMH), Mean (SD)	Paired Differences		t-Score	df
	WMH (Contralateral to NAWM), Mean (SD)	NAWM (Contralateral to WMH), Mean (SD)	Mean (SD)	95% CI Difference	t-Score	df
CVR (% BOLD/mm Hg)	0.05 (0.07)	0.13 (0.03)	0.06 (0.03)	0.05–0.07	14.8^{^a}	74
FA (unitless)	0.28 (0.07)	0.50 (0.11)	0.18 (0.04)	1.72–1.91	38.2^{^a}	74
MD (×10⁻³mm²/s)	1.37 (0.11)	0.84 (0.03)	0.51 (0.11)	0.48–0.54	40.7^{^a}	74
T2 (ms)	136.7 (14.4)	84.9 (4.9)	51.6 (11.8)	48.5–54.8	32.3^{^a}	53
CBF (mL/100 g/min)	18.2 (3.5)	21.0 (4.4)	1.9 (4.3)	0.16–3.7	2.8 (P = .01)	24
rCBV (AU)^{^b}	103.9 (10.1)	117.5 (9.3)	8.9 (19.7)	0.8–17.7	2.3 (P = .03)	24
MTT (s)	4.6 (0.5)	4.1 (0.3)	0.3 (1.1)	−0.1–0.8	1.5 (P = .15)	24
Tmax (s)	3.5 (0.3)	2.4 (0.2)	1.1 (0.8)	0.8–1.2	6.8^{^a}	24
TTP (s)	22.3 (1.3)	20.8 (1.0)	1.6 (1.2)	1.1–2.1	6.7^{^a}	24

Note:—FA indicates fractional anisotropy; rCBV, relative CBV; Tmax, time-to-maximum; AU, arbitrary units.
↵a P < .001 compared with contralateral WMH.
↵b These arbitrary units indicate that WMH are reduced compared to contralateral NAWM by 10.2%