Participant characteristicsa
| Young | Old | WMH | Stroke | P Value | |
|---|---|---|---|---|---|
| No. | 15 | 22 | 15 | 30 | |
| Age (range) (yr) | 25.7 ± 4.6 (20–36) | 69.1 ± 7.0b (55–81) | 72.0 ± 8.2b (51–83) | 67.9 ± 10.4b (51–88) | <.001 |
| Sex, female (%) | 7 (47) | 17 (77) | 8 (53) | 9 (30) | .009 |
| Hemodynamics | |||||
| ICA mean velocity (cm/s) | 18.2 ± 4.5 | 11.9 ± 2.9b | 10.3 ± 3.3b | 9.7 ± 3.1b | <.001 |
| ICA area (cm2) | 0.21 ± 0.04 | 0.24 ± 0.06 | 0.26 ± 0.06 | 026 ± 0.09 | .102 |
| VA mean velocity (cm/s) | 10.0 ± 2.5 | 6.7 ± 1.6b | 6.5 ± 1.7b | 5.6 ± 2.1b | <.001 |
| VA area (cm2) | 0.13 ± 0.03 | 0.13 ± 0.03 | 0.14 ± 0.04 | 0.12 ± 0.03 | .190 |
| PC-CBF (mL/100 g/min) | 49.0 ± 8.5 | 41.4 ± 8.1 | 40.6 ± 12.9 | 33.8 ± 6.3b,c | <.001 |
| ASL-CBF (mL/100 g/min) | 44.1 ± 10.2 | 40.8 ± 8.8 | 31.4 ± 9.6b,c | 34.3 ± 10.5b | <.001 |
Note:—VA indicates vertebral artery.
↵a Data are mean ± SD or count (proportion). Area and velocity are reported as the mean of bilateral vessels. ASL-CBF is uncorrected for labeling efficiency.
↵b Group differences compared with the young group at PBonferroni < .05.
↵c Group differences compared with the old group at PBonferroni < .05.