Table 3:

Associations between perinatal variables and postnatal brain growth

Perinatal VariableAdjusteda Growth (mm/week PNA)Interaction Termb (P Value)
β95% CI
Biparietal diameter
    GA
        <28 weeks1.881.71–2.05.002
        ≥28 weeks1.290.96–1.62
Corpus callosum length
    BW z score
        ≥−2 SD0.910.84–0.98.045
        <−2 SD0.730.57–0.89
    Postnatal corticosteroids
        No0.920.85–1.00.046
        Yes0.770.63–0.90
    Bronchopulmonary dysplasia
        No0.980.88–1.07.01
        Yes0.810.73–0.89
Transcerebellar diameter
    Antenatal corticosteroids
        No2.261.81–2.70.023
        Yes1.731.63–1.83
    Postnatal corticosteroids
        No1.841.74–1.95<.001
        Yes1.411.22–1.61
    Bronchopulmonary dysplasia
        No1.891.75–2.02.008
        Yes1.631.49–1.76
    Sepsis/NEC
        No1.821.71–1.93.016
        Yes1.551.36–1.74
Vermis height
    Postnatal corticosteroids
        No0.630.58–0.69.011
        Yes0.490.39–0.59
Ventricular width
    GA
        <28 weeks0.640.57–0.71.004
        ≥28 weeks0.410.27–0.55
  • a Adjusted for gestational age, birth weight z score, and sex.

  • b P value for the interaction between the perinatal variable and postnatal age.