Associations between perinatal variables and postnatal brain growth
Perinatal Variable | Adjusteda Growth (mm/week PNA) | Interaction Termb (P Value) | |
---|---|---|---|
β | 95% CI | ||
Biparietal diameter | |||
GA | |||
<28 weeks | 1.88 | 1.71–2.05 | .002 |
≥28 weeks | 1.29 | 0.96–1.62 | |
Corpus callosum length | |||
BW z score | |||
≥−2 SD | 0.91 | 0.84–0.98 | .045 |
<−2 SD | 0.73 | 0.57–0.89 | |
Postnatal corticosteroids | |||
No | 0.92 | 0.85–1.00 | .046 |
Yes | 0.77 | 0.63–0.90 | |
Bronchopulmonary dysplasia | |||
No | 0.98 | 0.88–1.07 | .01 |
Yes | 0.81 | 0.73–0.89 | |
Transcerebellar diameter | |||
Antenatal corticosteroids | |||
No | 2.26 | 1.81–2.70 | .023 |
Yes | 1.73 | 1.63–1.83 | |
Postnatal corticosteroids | |||
No | 1.84 | 1.74–1.95 | <.001 |
Yes | 1.41 | 1.22–1.61 | |
Bronchopulmonary dysplasia | |||
No | 1.89 | 1.75–2.02 | .008 |
Yes | 1.63 | 1.49–1.76 | |
Sepsis/NEC | |||
No | 1.82 | 1.71–1.93 | .016 |
Yes | 1.55 | 1.36–1.74 | |
Vermis height | |||
Postnatal corticosteroids | |||
No | 0.63 | 0.58–0.69 | .011 |
Yes | 0.49 | 0.39–0.59 | |
Ventricular width | |||
GA | |||
<28 weeks | 0.64 | 0.57–0.71 | .004 |
≥28 weeks | 0.41 | 0.27–0.55 |