Table 1:

Patient demographics and characteristics in NMOSD and MSa

NMOSDMSP Valuec
Demographics (NMOSD, n = 89) (MS, n = 89)
    Age (yr) (median) (IQR, range)51 (39–61, 16–85)36 (29–43, 18–67)<.001
        No. of femalesb77 (86.5)68 (76.4).12d
    Disease duration (yr) (median) (IQR, range)4 (0–11, 0–73)2 (1–7, 0–21).40
    EDSS (median) (IQR, range)6 (2–7.5, 1–9)2 (1–3, 0–6)<.001
    AQP4-IgGb
        Positive83 (93.3)
        Negative5 (5.6)
        Unknown1 (1.1)
    MS typeb
        Relapsing-remitting MS79 (88.8)
        Primary-progressive MS6 (6.7)
        Secondary-progressive MS2 (2.2)
        Unknown2 (2.2)
Brain MRI (NMOSD, n = 79) (MS, n= 87)
    Age (yr) (median) (IQR, range)50 (38–61, 17–83)36 (29–45, 19–67)<.001
        No. of femalesb68 (86.1)67 (77).16d
    Disease duration (yr) (median) (IQR, range)4 (0–11, 0–41)3 (1–7, 0–21).59
    EDSS (median) (IQR, range)6 (2–7.5, 1–9)2 (1–3, 0–6)<.001
    Gadolinium enhancementb51 (64.6)68 (78.2)
Spinal cord MRI (NMOSD, n = 57) (MS, n = 55)
    Age (yr) (median) (IQR, range)53 (39–61, 25–78)37 (29–43, 18–66)<.001
        No. of femalesb51 (89.5)36 (65.5).003d
    Disease duration (yr) (median) (IQR, range)4 (0–12, 0–43)2 (0–7, 0–19).18
    EDSS (median) (IQR, range)6 (2–7, 1–9)2 (2–3.5, 0–6)<.001
Optic nerve MRI (NMOSD, n = 42) (MS, n = 14)
    Age (yr) (median) (IQR, range)50 (37–61, 17–79)35 (34–39, 19–67).004
        No. of femalesb37 (88.1)9 (64.3).10d
    Disease duration (yr) (median) (IQR, range)5 (0–12, 0–42)1 (0–6, 0–17).15
    EDSS (median) (IQR, range)6 (3–8, 1–9)3 (2–3.5, 2–4).065

  • Note:—EDSS indicates Expanded Disability Status Scale.

  • ↵a Unless otherwise indicated, data are medians, with interquartile range and total range in parentheses.

  • ↵b Data in parentheses are percentages.

  • ↵c Mann-Whitney U test.

  • ↵d Fisher exact test.