Table 2:

Number and size of brain lesions for rater 1 and assessment of brain morphologic features and characteristic signs

Quantitative Analyses	NMOSD (n = 79)	MS (n = 87)	P Value	Accuracy	κ Value
Total No. of lesions	911	1659
Per patient^{^a}	5 (1–18, 0–81)	8 (3–28, 0–120)	.004^{^c}
Diameter of lesions (mm)^{^a}	5.7 (4.3–8.5, 3.0–45)	6.1 (4.6–8.3, 3.0–56)	.046^{^c}
In each region (mm)^{^a}
PVWM	9.2 (5.3–14, 3.0–36)	6.8 (5.1–9.5, 3.0–47)	<.001^{^c}
DWM	5.5 (4.2–7.7, 3.0–45)	5.5 (4.3–7.4, 3.0–56)	.73^{^c}
SCWM	5.4 (3.7–7.2, 3.0–28)	5.9 (4.5–7.9, 3.0–25)	.054^{^c}
DGM	5.9 (4.3–8.3, 3.1–30)	6.7 (5.5–9.2, 3.5–48)	.31^{^c}
BS	6.2 (5.3–8.3, 3.3–22)	6.9 (5.2–8.1, 3.6–16)	.96^{^c}
Cerebellum	3.7 (3.7–3.7, 3.7–3.7)	7.3 (5.5–8.9, 3.4–21)	.17^{^c}
Morphologic assessment
Brain atrophy^{^b}	4 (5.1)	5 (5.7)	1^{^d}	0.48	0.52
Ventriculomegaly^{^b}	3 (3.8)	3 (3.4)	1^{^d}	0.48	0.5
Characteristic signs
Ovoid lesions^{^b}	17 (21.5)	55 (63.2)	<.001^{^d}	0.71	0.68
T1 black hole lesions^{^b}	16 (20.3)	47 (54)	<.001^{^d}	0.66	0.65
Callosal-septal-interface lesions^{^b}	23 (29.1)	48 (55.2)	.001^{^d}	0.63	0.75
Isolated U-fiber lesions^{^b}	8 (10.1)	24 (27.6)	.005^{^d}	0.57	0.56
Dirty white matter lesions^{^b}	13 (16.5)	23 (26.4)	.14^{^d}	0.54	0.61
Tumefactive MS lesions^{^b}	1 (1.3)	2 (2.3)	1^{^d}	0.48	0.74
Cloudlike enhancement^{^b}	0 (0)	0 (0)