Table 1:

Clinical and MRI characteristics of RIS participants

Clinical Characteristics
    Participants (No.)20
    Age (mean) (SD) (yr)46 (11)
    Female (No.) (%)15 (75%)
    No. of cases with positive oligoclonal band (No.) (%)a5 (83%)
MRI characteristics
    Brain lesions
        Total brain lesion count (No.)997
        No. of brain lesions per case (median) (range)33 (9–165)
        Total brain lesion volume (median) (range) (cm3)b3.9 (0.3–17.9)
        No. of cases with T1 black hole lesions (No.) (%)15 (75%)
        No. of T1 black hole lesion count206 (21%)
        No. of T1 black hole lesions per case (median) (range)3.5 (0–43)
        No. of brain lesions included in the analysis (No.) (%)391 (39%)
        No. of brain lesions excluded from analysis (No.) (%)606 (61%)
        Brain volume (median) (range) (cm3)b1208 (1066–1468)
        Cerebral volume fraction (median) (range)b0.90 (0.88–0.91)
    No. of assessed brain lesion/total brain lesion by region (%)
        Cortical/juxtacortical90/193 (47%)
        Subcortical/deep228/562 (40%)
        Periventricular60/203 (30%)
        Infratentorial13/39 (33%)
    Cervical spinal cord lesions
        No. of cases with spinal cord lesions (No.) (%)13 (65%)
        Total spinal cord lesion count30
    No. of spinal cord lesions per case (median) (range)1 (0–4)

  • ↵a CSF analysis for oligoclonal bands was available in 6 of 20 cases.

  • ↵b Automated brain lesion volume measurements were obtained from 18 cases (n = 18). Automated brain segmentation failed in 2 cases.