Brain morphometry analysis according to the iCL status
| Structures, Median, and (25th, 75th Percentile) | iCL-Negative Subgroup (n = 16) | iCL-Positive Subgroup (n = 55) | P Value |
|---|---|---|---|
| Median of ICV (mL) (25th, 75th percentile) | 1374.49 (1282.47–1482.68) | 1343.47 (1260.50–1432.01) | .53 |
| Subcortical gray matter volume (median) % ICV (25th, 75th percentile) | 4.36 (3.93–4.42) | 4.01 (3.75–4.23) | .02a |
| Thalamus volume (median) % ICV (25th, 75th percentile) | 1.03 (0.99–1.097) | 0.99 (0.93–1.09) | .22 |
| Caudate volume (median) % ICV (25th, 75th percentile) | 0.56 (0.48–0.598) | 0.49 (0.46–0.55) | .03a |
| Putamen volume (median) % ICV (25th, 75th percentile) | 0.81 (0.75–0.88) | 0.74 (0.68–0.82) | .02a |
| Pallidum volume (median) % ICV (25th, 75th percentile) | 0.23 (0.20–0.25) | 0.20 (0.17–0.22) | .005a |
| Volume of WML (median) % ICV (25th, 75th percentile) | 0.39 (0.16–0.57) | 0.65 (0.31–1.34) | .01a |
| iCL lesions volume (median) % ICV (25th, 75th percentile) | – | 0.008 (0.004–0.02) | – |
↵a Significant difference.