Microbleeds (yes versus no) and white matter microstructure integritya
FA | MD | Axial Diffusivity | Radial Diffusivity | |||||
---|---|---|---|---|---|---|---|---|
β | P | β | P | β | P | β | P | |
Model 1 | −0.450 (−0.616 to −0.285) | <.001 | 0.433 (0.282−0.584) | <.001 | 0.378 (0.221−0.535) | <.001 | 0.446 (0.295−0.597) | <.001 |
Model 2 | −0.433 (−0.597 to −0.269) | <.001 | 0.420 (0.271−0.570) | <.001 | 0.368 (0.212−0.524) | <.001 | 0.432 (0.282−0.581) | <.001 |
Model 3 | −0.238 (−0.394 to −0.083) | .003 | 0.204 (0.068−0.340) | .003 | 0.165 (0.019−0.310) | .026 | 0.217 (0.081−0.352) | .002 |
Model 4 | −0.241 (−0.396 to −0.086) | .002 | 0.206 (0.070−0.342) | .003 | 0.167 (0.021−0.312) | .025 | 0.218 (0.083−0.354) | .002 |
Note:—β indicates regression coefficient.
↵a Values represent differences in z scores of mean FA, MD, axial diffusivity, and radial diffusivity of NAWM for the presence of any microbleeds compared with no microbleeds. Model 1: adjusted for age and sex; model 2: same as model 1, additionally adjusted for hypertension, hyperlipidemia, smoking, diabetes; model 3: adjusted for age, sex, lacunes, and white matter hyperintensity volume (log-transformed); model 4: adjusted for sex, cardiovascular risk factors as in model 2, and CSVD imaging markers as in model 3.