Results from multiple regression analysis examining associations between neurometabolites and clinical disability measuresa
| Predictors | Standardized β | Standardized 95% CI | P |
|---|---|---|---|
| Nine-Hole Peg Test (n = 118)b | |||
| NAWM tNAA/tCr | 0.19 | 0.01–0.36 | .04 |
| Paced Auditory Serial Addition Test (n = 119) | |||
| NAWM tNAA | 0.17 | 0.01–0.34 | .04 |
| Sexc | –0.23 | –0.42 to –0.05 | .01 |
| T2 lesion volume | –0.47 | –0.64 to –0.30 | <.001 |
| Paced Auditory Serial Addition Test (n = 118)d | |||
| NAWM tNAA/tCr | 0.19 | 0.03–0.35 | .02 |
| Sexc | –0.26 | –0.44 to –0.08 | .006 |
| T2 lesion volume | –0.46 | –0.63 to –0.29 | <.001 |
| Paced Auditory Serial Addition Test (n = 119) | |||
| NAWM mIns/tCr | –0.22 | –0.39 to –0.06 | .007 |
| Sexc | –0.25 | –0.43 to –0.07 | .008 |
| T2 lesion volume | –0.47 | –0.64 to –0.30 | <.001 |
| Paced Auditory Serial Addition Test (n = 119) | |||
| GM tCho | –0.17 | –0.33 to –0.01 | .04 |
| T2 lesion volume | –0.48 | –0.65 to –0.31 | <.001 |
↵a Covariates in the model include age, sex, duration from onset, occurrence of relapse in the 2 years preceding randomization, T2 lesion volume, and normalized brain volume. The table highlights only the predictor variables that were significant from the multiple regression models.
↵b The Nine–Hole Peg Test was calculated by taking the reciprocal of the average of 2 trials for each arm and taking the mean.
↵c Male is reference category.
↵d One hundred eighteen participants in this cohort because 1 case was removed due to a highly leveraged point.