Association between PSMD and MRI markers of small-vessel disease in subjects with CAA-MCI and non-CAA-MCIa
| Model 1b | Model 2c | |||||||
|---|---|---|---|---|---|---|---|---|
| Std. β | 95% CI | P | Std. β | 95% CI | P | |||
| CAA-MCI (n = 24) | ||||||||
| Lobar CMB count | 0.15 | –0.27 | 0.58 | .46 | 0.15 | –0.13 | 0.42 | .28 |
| cSS | 0.27 | –0.15 | 0.70 | .20 | 0.12 | –0.16 | 0.40 | .38 |
| CSO-PVS score | 0.31 | –0.09 | 0.71 | .13 | 0.20 | –0.10 | 0.49 | .18 |
| nWMHV | 0.75 | 0.49 | 1.02 | <.001d | 0.66 | 0.37 | 0.95 | <.001d |
| nTBV | –0.26 | –0.79 | 0.26 | .31 | –0.17 | –0.54 | 0.20 | .34 |
| Non-CAA-MCI (n = 62) | ||||||||
| CSO-PVS | –0.02 | –0.24 | 0.21 | .87 | 0.10 | –0.07 | 0.27 | .25 |
| nWMHV | 0.69 | 0.50 | 0.89 | <.001d | 0.71 | 0.51 | 0.91 | <.001d |
| nTBV | –0.23 | –0.51 | 0.06 | .11 | –0.14 | –0.36 | 0.08 | .20 |
Note:—Std. β indicates standardized beta coefficient.
↵a Linear regression models with PSMD (×10−4 mm2/s) as the dependent variable.
↵b Simple Linear regression analyses adjusted for age.
↵c Multiple regression models, including all neuroimaging markers and adjusted for age. In subjects with non-CAA-MCI, the presence of cSS and lobar CMB count was automatically excluded from the models due to the absence of variance within the group.
↵d Significant.