Demographic, clinical, and conventional MRI characteristics of the studied populationa
| MS (n = 91) | HC (n = 55) | P Value (MS vs HC) | |
|---|---|---|---|
| Age (yr) | 38.3 (SD, 11.1) | 41.6 (SD, 13.9) | .14 |
| Female sexb | 54 (59.3) | 27 (49.1) | .23 |
| Use of DMTb | 83 (91.2) | – | – |
| Progressive courseb | 20 (22.0) | – | – |
| DD (yr) | 11.2 (SD, 7.0) | – | – |
| EDSSc | 3.5 (2.5–4.5) | – | – |
| T2-LL (mL) | 11.4 (SD, 13.3) | – | – |
| Normalized brain volume (mL) | 1485.8 (SD, 88.6) | 1552.9 (SD, 76.4) | <.001 |
| Normalized GM volume (mL) | 755.6 (SD, 62.8) | 794.7 (SD, 57.5) | <.001 |
| Normalized WM volume (mL) | 730.2 (SD, 36.5) | 758.2 (SD, 31.7) | <.001 |
Note:—– indicates not applicable; DMT, disease-modifying treatment.
↵a Unless otherwise indicated, data are expressed as means (SD). Between-group differences regarding MRI measures are adjusted for age and sex.
↵b Data are the number of subjects, with percentages in parentheses.
↵c Data are medians, with interquartile range in parentheses.