TABLE 3:

Location of the greatest gray matter reduction in the cluster regions of significant gray matter density reduction in early-onset and late-onset AD groups compared with age-, sex-, and severity-matched control subjects

Group and Location	Z Value	x	y	z
YHC > EO
Right parahippocampal gyrus	5.79	17	−36	0
Left inferior parietal lobule	5.06	−45	−50	41
Right inferior parietal lobule	4.77	38	−62	41
Left operculum	4.72	−41	−13	−6
Right inferior frontal gyrus	4.50	41	8	30
Right precuneus	4.25	15	−65	14
Left inferior parietal lobule	3.96	−47	−58	23
OHC > LO
Left hippocampus	5.13	−26	−7	−16
Right hippocampus	4.35	25	−38	−4

Note.—YHC indicates younger healthy controls; EO, early-onset AD; OHC, older healthy controls; LO, late-onset AD. Threshold is P < .001, uncorrected.