Layered neuropathology diagnosisa
| Brain (right frontal) |
|---|
| Integrated diagnosis: glioblastoma, IDH-wildtypeb |
| Histologic diagnosis: diffuse astrocytic tumor with mitotic figures |
| WHO CNS grade: 4 |
| Molecular information: |
| IDH: wildtype (DNA sequencing) |
| ATRX: retained nuclear expression, consistent with wild-type (immunohistochemistry) |
| p53: rare positive cells, consistent with wild-type (immunohistochemistry) |
| EGFR: amplified (FISH) |
↵a Illustrative example of a layered neuropathology report beginning with site and identifier and with integrated diagnosis as the top line.
↵b Although this tumor lacks microvascular proliferation and necrosis, the presence of EGFR amplification necessitates a diagnosis of glioblastoma in an IDH-wildtype diffuse astrocytic glioma.