Table 2:

Characteristics and results of the cases with astrocytoma, IDH-mutant, CNS WHO grades 2–4

CaseAge (yr)SubgroupFusion/Methylation AnalysisT2-FLAIR Mismatch Sign (S) or Area (A)Histology
MicrocystsEnlarged Intercellular Spaces
1217.7IDH +, WHO 2IDH (R132H), ATRX, TP53+ (A)++
139.2IDH +, WHO 2IDH (R132H), TP53++
1418.7IDH +, WHO 2IDH (R132H), ATRX, TP53+ (S)+
1514.0IDH +, WHO 2IDH (R132H), ATRX, TP53++
1610.6IDH +, WHO 2IDH (R132H), TP53+
174.0IDH +, WHO 2IDH (R132H), PIK3CA, NF1+
1817.1IDH +, WHO 3IDH (R132H), PTEN, TP53++
1915.6IDH +, WHO 4IDH (R132H), TP53, MSH6, ATRX, CDKN2A, CIC.
  • Note:—The + indicates presence; −, absence of the characteristic.