Differences in absolute metabolite concentrations (and SE, in mM in aqueous fraction) in NAWM between patients with MS (and normal MRI scan of the brain) and control subjects
| Absolute Metabolite Concentration | Patients, mM | Control Subjects, mM | P (Mann-Whitney) | P (2-way ANOVA) |
|---|---|---|---|---|
| Cho | ||||
| Mean | 2.16 | 2.38 | <.001 | <.001 |
| SE | 0.04 | 0.05 | ||
| Cr | ||||
| Mean | 7.03 | 7.35 | .029 | .013 |
| SE | 0.07 | 0.10 | ||
| m-Ins | ||||
| Mean | 6.38 | 6.18 | n.s. | n.s. |
| SE | 0.15 | 0.13 | ||
| NAA | ||||
| Mean | 10.26 | 10.96 | .003 | .004 |
| SE | 0.16 | 0.19 | ||
| tNA | ||||
| Mean | 13.54 | 14.62 | .002 | <.001 |
| SE | 0.21 | 0.26 |
Note:—Cho indicates choline; Cr, creatine; m-Ins, myo-inositol; NAA, N-acetylaspartate; tNA, total N-acetyl compounds including NAA and NAAG; n.s., not significant; MS, multiple sclerosis; NAWM, normal-appearing white matter.