BFR and BCR, T2-relaxation time, ADC, MTR and NAA/Cr ratio mean value differences between the test and control groups, measured at the NAWM and CC
| MRI Technique and Region | Test Group (mean) | Control Group (mean) | P Value |
|---|---|---|---|
| BFR (%) | 28.2 ± 2.9 | 21.8 ± 2.5 | .0001 |
| BCR (%) | 18.2 ± 2.7 | 11.1 ± 1.2 | <.0001 |
| T2-relaxation time at NAWM (ms) | 106.3 ± 2.1 | 98.1 ± 2.0 | <.0001 |
| T2-relaxation time at CC (ms) | 94.7 ± 2.5 | 89.4 ± 2.0 | .0004 |
| ADC at NAWM (× 10−11 m2/s) | 99.9 ± 6.4 | 85.4 ± 6.4 | .0061 |
| ADC at CC (× 10−11 m2/s) | 100.7 ± 10.7 | 80.9 ± 2.2 | <.0001 |
| MTR at NAWM (%) | 26.9 ± 1.2 | 28.8 ± 0.7 | .0358 |
| MTR at CC (%) | 28.1 ± 1.2 | 30.1 ± 1.1 | .0118 |
| NAA/Cr at NAWM | 2.28 ± 0.07 | 2.43 ± 0.11 | .2750 |
| NAA/Cr at CC | 1.81 ± 0.20 | 2.21 ± 0.26 | .0027 |
Note:—MRI indicates MR imaging; BFR, bifrontal ventricle-to-brain ratio; BCR, bicaudate ventricle-to-brain ratio; ADC, apparent diffusion coefficient; MTR, magnetization transfer ratio; NAA/Cr, N-acetylaspartate/creatine; NAWM, normal-appearing white matter; CC, corpus callosum.