Table 1:

Independent variablesa

Variables
Clinical
    AgeQuantitative variable
    SexCategorized: 1) male, 2) female
    Initial glycemiaQuantitative variable
    Fibrinolytic treatmentCategorized: 1) yes, 2) no
    Initial NIHSS scoreQuantitative variable
Imaging
    FLAIR volumeQuantitative variable
    Persistent occlusionbCategorized: 1) yes, 2) no
    Percentage of reperfusioncCategorized: 0) no significant abnormality on PWI-1,d 1) reperfusion between TP1 and TP2 ≥90%; 2) Reperfusion between TP1 and TP2 < 90%

  • a Independent variables were introduced in multivariable analyses because of their potential association with final infarct volume and clinical recovery.34–36 Quantitative variables were introduced as continuous variables or by class according to quartiles if the hypothesis of linearity was not graphically met.

  • b Persistent occlusion was defined as an occluded artery on MRA-1 remaining occluded on MRA-2 in an acute stroke territory.

  • c Reperfusion definition was based on PWI at TP1 and TP2, calculated as follows: (PWI-1 − PWI-2)/PWI-1 × 100. Ninety percent was chosen as a threshold because it was previously reported to be associated with final volume and clinical outcome.36

  • d PWI abnormalities were considered on TTP maps using a delay of 4 seconds or more. TP1 indicates <12 hours; TP2, days 3–6.